The Comfort Inn Indianapolis South is located at the junction of Interstate 465 Exit US 31, ten minutes south of downtown Indianapolis, Conseco Fieldhouse, and RCA Dome. The hotel offers a complimentary continental breakfast. On-site facilities include the outdoor seasonal pool and conference room. The hotel is located three miles from the University of Indianapolis, four miles from Indiana Pacers and Conseco Fieldhouse, and 15 miles from Indianapolis Raceway Park. Within eight miles of the hotel are Circle City Classic, downtown Indianapolis, Indianapolis Colts, RCA Dome, Indianapolis Zoo, Marion County Fairgrounds, Comfort Classic, Brickyard Crossing Golf Course, War Memorial Plaza, Indianapolis Motor Speedway, and Brickyard 400. Each room has one king or two queen beds, dataport telephone, satellite television, radio, and free local calls and newspapers.

The Comfort Inn Indianapolis South is approximately eight miles from the Indianapolis International Airport.