The Siena Hotel Spa and Casino is located on the Truckee River banks, across from the National Automobile Museum, and approximately three miles from Reno-Tahoe International Airport. Local attractions include Pioneer Center, Reno Arch, Nevada Museum of Art, and Reno-Sparks Convention Center. Onsite drinks and dining options include Lexie's on the River, Contrada Cafe, and Enoteca, a wine bar. The Spa at Siena features aromatherapy, facials, manicures, massage therapy, and specialized treatments. There is an adjacent fitness room, gift shop, outdoor lap pool, and spa tub. Also on the premises is a 24-hour casino including table games, slot machines, and a sports book. Guest rooms feature luxury linens, down comforters, refrigerators, dual-line speakerphones, high-speed Internet access, Web TV, dataports, desks, and in-room safes. .

The Siena Hotel Spa and Casino is located on the Truckee River banks, across from the National Automobile Museum, and approximately three miles from Reno-Tahoe International Airport.